Job Openings

Corporate Strategy, Operations & Partnerships, Senior Associate

Canton (Greater Boston), MA

This is a highly impactful, and vital position created at the intersection of overlapping areas of Pledge’s strategy, operations, and partnerships.

Job Description:

This is a highly impactful, and vital position created at the intersection of overlapping areas of Pledge’s strategy, operations, and partnerships. The successful candidate is an analytical and strategic individual with intuitive intelligence and an entrepreneurial spirit. You will play an essential role in shaping the direction and evolution of Pledge’s unique portfolio-oriented business model. Whether you are interested in operational, managerial or VC/PE career paths, this role will provide substantive exposure and opportunities to grow. The ideal candidate will have a blend of scientific, financial, and business expertise.

Key Responsabilities:

  • Assess the strategic fit and commercial opportunity of portfolio assets, including market sizing, competitive landscape scanning, revenue forecasts, and investment requirements.
  • Identify attractive investment areas by analyzing unmet medical needs and opportunities and networking with leading industry executives, academics, entrepreneurs, and other venture professionals.
  • Support partner interactions and conduct term sheet and contract negotiations.
  • Support senior management in investor and external partner relationships, ensuring regular and efficient communication with key stakeholders.
  • Enable corporate strategic planning, positioning, and portfolio optimization by providing required input and assessments and developing content and presentations for senior management and the Executive Committee.
  • Actively surveil the drug discovery portfolio via regular innovation strategy reviews, assessing key risks and opportunities for drug pipeline prioritization.
  • Build and maintain financial and investment return models for portfolio companies, performing market, competitive, and exit analyses.
  • Support or lead evaluation of key business questions through primary and secondary market research, data analysis, and cross-functional assessments across the company
  • Perform scientific and business due diligence with consultants, key opinion leaders, and clinicians related to specific portfolio companies or investment opportunities.
  • Translate research & analysis into actionable business insights to inform disease area strategies and priorities and identify areas for investment.
  • Act as a liaison between stakeholders across the business, scientific, and operational streams—driving the execution of strategic and tactical initiatives.
  • Ensure organizational efficiency by mediating team agendas in R&D and business strategy meetings.
  • Support the senior leadership in identifying and pursuing strategic priorities and developing material and content to support partnership and investment activities.
  • Generate slide deck presentations, executive summaries, and diligence or investment memos that succinctly describe, interpret, analyze, and summarize business and scientific information.

Professional Experience and Qualifications:

  • An MBA or science-related graduate degree is highly preferred; a bachelor’s degree (minimum);
  • 2+ years of experience in top-tier management consulting, life sciences strategy, or business development roles is required.
  • Experience working in venture capital, private equity, or high-performance biotech start-ups is highly preferred.
  • Understanding of biopharma fundamentals, drug development stage gates, and industry-specific dynamics.
  • Solid understanding of industry-relevant economic, financial, and general business concepts and terminology.
  • Quick learner of the fundaments of new diseases, therapeutic areas, market dynamics, opportunities, trends, and risks by leveraging internal and external expertise.
  • Strong quantitative and financial skills with the ability to make and deliver effective, compelling presentations and concise, clear memos and emails.
  • Facile in assembling and analyzing information from primary and secondary data sources to arrive at recommendations, insights, and solutions.
  • Demonstrated experience in supporting business development, and due diligence, including market sizing, forecasting, execution of market research, data analytics, and creation of buy-side or sell-side reports and business cases.
  • Demonstrated leadership qualities with the ability to outline a problem, define strategy, develop project goals, and drive strategic and corporate outcomes.
  • Experience working in dynamic, productive, cross-functional, cross-matrix environments. Global and international experience is preferred.
  • Track record of initiative and execution while maintaining an emphasis on multiple work streams.
  • Possess outstanding organizational abilities with a collaborative, tactful, and goal-oriented working style.
  • Desire to work in a fast-paced start-up environment with an ability to exercise judgment on competing priorities.
  • Exceptional focus and attention to detail, adherence to strict timelines and deadlines.
  • Flexible, entrepreneurial, resourceful, and efficient – with a problem-solving attitude.
  • An analytical, clear thinker who is comfortable navigating through ambiguity, quickly building a knowledge base, formulating, and validating assumptions.
  • Ability to communicate complex ideas effectively – both verbally and in writing
  • PowerPoint and Excel guru – proficient with data visualization using productivity software tools

If you are ready to contribute to innovative research projects and be part of a growing company that is tackling some of the most pressing healthcare issues in modern medicine, please send us your CV and cover letter to info@pledge-tx.com.

Job Type: Full-time, On-site, USA work permit, Equal Opportunity Employment. 

Scientist, Molecular Biology, Virology

Canton (Greater Boston), MA

This is a position for a driven, and creative Scientist ready to immerse themselves in cutting-edge workflows and techniques within virology.

Job Description:

Pledge Therapeutics is in search of an enthusiastic, driven, and creative Scientist ready to immerse themselves in cutting-edge workflows and techniques within virology. This role entails providing crucial input to the R&D team for the advancement of our anti-viral portfolio. The ideal candidate is reliable, independent, and initiative-driven, showcasing exceptional organizational skills, attention to detail, and effective written and oral communication. Preference will be given to candidates with exposure to drug discovery.

Key Responsibilities:

  • Conduct diverse cell-based and biochemical assays related to our viral targets
  • Develop biochemical assays to elucidate the mechanism of action of anti-viral compounds
  • Deploy virology techniques for high-throughput screening drug discovery deriving unique insights from biological data
  • Maintain primary and immortal cell lines

 

Professional Experience and Qualifications:

  • Ph.D. degree in Virology, Molecular Biology, Infectious Diseases or a related scientific field of study. Industry experience required
  • Experience in virology and/or biochemistry, techniques: recombinant DNA techniques, RNA isolation, cell culture, transfections, virus production, amplification, viral quantitation, identification of optimal virus MOI etc
  • Proficiency in assay development
  • Preferred hands-on experience in hit-generation, advancing small molecule or antiviral drugs through lead optimization to candidate selection
  • High attention to detail, with a proven ability to manage multiple priorities simultaneously.
  • Ability to thrive in a fast-paced, start-up environment

 

If you are ready to contribute to innovative research projects and be part of a growing company that is tackling some of the most pressing healthcare issues in modern medicine, please send us your CV and a note to info@pledge-tx.com.

Job Type: Full-time, On-site, USA work permit, Equal Opportunity Employment. 

Research Associate Molecular Biology

Canton (Greater Boston), MA

This is a position for an enthusiastic scientist interested in taking part in all aspects of the hit-to-lead drug discovery process.

Job Description:

We seek an enthusiastic scientist interested in taking part in all aspects of the hit-to-lead drug discovery process. The opening is at our new state-of-the-art facility in Canton, MA. The successful candidate will engage in different research areas of the company and will work with a successful team of international senior scientists located in the USA and EU. The ideal candidate will have great communication skills, excellent technical skills, exemplary attention to detail, and a passion for learning. This position will have the opportunity to become part of an exciting, startup company and make significant scientific contributions to numerous drug discovery projects.

Key Responsibilities:

  • Maintain multiple mammalian cell lines and optimize them for viral production and viral assays
  • Perform in-vitro experiments with flexibility and precision, meeting ongoing demands and establishing best practices to maximize tissue culture outputs
  • Conduct High Throughput Screening of compounds or libraries using DSF and ELISA assay techniques, among others
  • Maintain excellent written records of performed experiments, and work with colleagues to develop companywide SOPs
  • Prepare reports of completed projects for presentation to company personnel
  • Help organize laboratory inventory, reagent ordering, and other daily or extraordinary laboratory activities
  • Provide additional research support and assistance to research tasks requested by senior management
  • Collaborates cross-functionally with other team members to ensure that daily operations and timelines are met

Professional Experience and Qualifications:

  • Bachelor’s of Science or Master in Sciences degree in cellular or molecular biology, or related field and 1-2 years of experience
  • Previous laboratory experience in tissue culture and viral production
  • Organized with a strong work ethic and the ability to juggle different tasks
  • Able to work in a team and willing to present data to our international partners


If you are ready to contribute to innovative research projects and be part of a growing company that is tackling some of the most pressing healthcare issues in modern medicine, please send us your CV and a note to info@pledge-tx.com.

Job Type: Full-time, On-site, USA work permit, Equal Opportunity Employment.

Senior Scientist, NK Cell, In-vitro

Canton (Greater Boston), MA

This is a position for a driven, and creative Scientist capable of solving the challenges associated with drug discovery.

Job Description:

We seek an enthusiastic, driven, and creative scientist capable of solving the challenges associated with drug discovery. The successful candidate will work with an international and multidisciplinary team of scientists engaging different research arms of the company including protein production, assay development, and cellular biology for drug screening. Exposure to drug discovery and cell-based oncology/immunology assays will be preferred.

The ideal candidate will have exceptional communication skills, superior technical skills, and exemplary attention to detail. This position will have the opportunity to become part of a dynamic, interdisciplinary R&D team and make significant scientific contributions to numerous drug discovery projects. There will be substantial opportunities to grow with the company.

 

Key Responsibilities:

 

  • Investigate the effect of small molecules and biologics on the function of T and NK cells
  • Lead research projects, developing strategic visions and project goals
  • Establish and execute a variety of biochemical/cell-based immunological in vitro assays
  • Independently analyze, interpret, and present data at internal meetings
  • Maintain experimental records in an electronic notebook
  • Stay updated with relevant scientific literature and propose new experimental strategies and approaches
  • Effectively communicate and collaborate with members of the R&D team
  • Serve as a leader and mentor to junior team members

 

Professional Experience and Qualifications:

Required:

  • PhD in immunology or related field, with 0-5 years of relevant experience in laboratory research settings
  • Expertise in T and NK cell killing experiments, ADCC
  • Extensive hands-on experience with immuno-phenotyping by multi-color FACS (12+), PBMCs, ELISA, ADCC, MLR, cytotoxicity, western blot and cell-based assays to analyze immune cells in BSL2 laboratory
  • Proficiency in GraphPad and Flow Jo
  • Ability to work independently with minimal supervision
  • Strong analytical, organizational, communication and time management skills

Preferred:

  • Industry experience
  • Experience with small molecules and antibodies

 

If you are ready to contribute to innovative research projects and be part of a growing company that is tackling some of the most pressing healthcare issues in modern medicine, please send us your CV and a note to info@pledge-tx.com.

Job Type: Full-time, On-site, USA work permit, Equal Opportunity Employment. 

Postdoctoral Associate: AI for Drug Discovery (Deep Learning / Machine Learning)

Canton (Greater Boston), MA

This is a position for a scientist who excels in machine learning model development, building and deploying models for lead optimization, and multi-parameter optimization.

Job Description:

We are actively seeking an enthusiastic scientist interested in playing a pivotal role in our hit-to-lead drug discovery process. The ideal candidate will possess expertise in designing, developing, and optimizing state-of-the-art generative chemistry models, leveraging the ligand and receptor structure properties. Additionally, the candidate should excel in machine learning model development, including building and deploying models for lead optimization, multi-parameter optimization, and handling sparse inputs. In this role, you will play a key part in the integration of deep learning and machine learning into computational chemistry.

Collaboration and cross-functional communication are paramount. The successful candidate will work closely with machine learning specialists, computational chemists, medicinal chemists, biophysicists, and biologists. This collaboration aims to deepen the understanding of the drug discovery process and enhance discovery pipelines by developing and implementing customized and optimized deep learning and machine learning solutions.

Key Responsibilities:

  • Development of Deep Learning Models: Design, develop, and optimize state-of-the-art generative chemistry models that leverage the ligand and receptor structure properties
  • Machine Learning Model Development: Build and deploy machine learning models for the lead optimization – multi parameter optimization and sparse input handling
  • Integration of Deep Learning and Machine Learning into Computational Chemistry: Integrate DL and ML methodologies with state of the art computational chemistry pipelines to harness physics-based calculations with data-driven insights to improve accuracy and efficiency in predictive modeling
  • Collaboration and Cross-Functional Communication: Work closely with machine learning specialists, computational chemists, medicinal chemists, biophysicists, and biologists to comprehend the nuances of the drug discovery process and improve discovery pipelines by developing and employing customized and optimized deep learning and machine learning solutions
  • Model Training and Testing: Determining and implementing scalable computing resources for training machine learning models, while simultaneously ensuring model reliability through extensive testing and benchmarking
  • Performance Optimization: Continually enhance machine learning models and algorithms to boost prediction accuracy, computational efficiency, and the general performance of the system


Professional Experience and Qualifications:

  • Ph.D. in Computer Science, Computational Chemistry, Chemical Engineering Bioinformatics, or a related field.
  • Proven experience in building and deploying machine learning models (Preference for small molecule and protein structure-based deep learning models)
  • Expertise in computer science, computational chemistry, cheminformatics
  • Exposure to structure-based rational drug discovery principals
  • Proficiency in programming languages such as Python, and experience with machine learning frameworks and libraries like TensorFlow, PyTorch, scikit-learn, etc.
  • Excellent problem-solving skills and the ability to work in a collaborative, fast-paced team environment


If you are ready to contribute to innovative research projects and be part of a growing company that is tackling some of the most pressing healthcare issues in modern medicine, please send us your CV and a note to info@pledge-tx.com.

Job Type: Full-time,  USA work permit, Equal Opportunity Employment.