Job Openings

Canton (Greater Boston), MA
The Project Leader will advance our antiviral drug programs, set project strategy, and lead execution.

Job Description:

We strongly believe that unlocking innovative medicines requires the close cooperation of dynamic teams spanning disease biology, protein biochemistry, data science, structural biology, biophysics, and medicinal chemistry.

Interlinking all these nodes at Pledge is a Project Leader who is accountable for the success of a project. The Project Leader will have autonomy and resources to prosecute projects rapidly, efficiently, and to the highest scientific standards. Project leaders are vital pillars of our operational model and success.

We seek a highly motivated, experienced R&D Project Leader with a track record of leading antiviral and infectious diseases therapeutic projects across the discovery and preclinical spectrums. The Project Leader will be responsible for advancing our  antiviral drug programs, setting project strategy, and leading execution. The candidate will have a “roll-up-your-sleeves” attitude and will be comfortable with bench-work just as much as driving the program forward through the deployment of internal and external resources. The successful candidate will define the path to drug discovery from hit-generation to candidate selection with compelling data packages in line with our corporate goals.

The Project Leader will work closely with medicinal and computational chemistry colleagues, biophysicists, and a team of research associates in identifying, characterization, and advancing high-quality drug candidates through preclinical development and IND studies, including proof-of-mechanism endpoints. The candidate will develop collaborative partnerships within the company and with external collaborators, including academic investigators and contract research organizations (CROs).

 

Key Responsibilities:

  • Directly lead small-molecule, infectious and antiviral drug discovery programs, overseeing all phases of project execution with a focus on R&D outcomes.
  • Develop and establish assays (antiviral, cytotoxicity, and/or intracellular assays) to support hit-to-lead (H2L) and lead optimization as well as antiviral high throughput screening (HTS) campaigns.
  • Deploy sophisticated virology techniques for high-volume, high-speed drug discovery deriving unique insights from biological data
  • Design and perform mechanism of action studies.
  • Create and implement project strategies to identify high-quality development drug candidates, identify key decision points, and manage risk.
  • Identify and develop short-, mid-, and long-term R&D objectives alongside senior management.
  • Prioritize and coordinate research activities and allocate resources between internal staff and external contract research organizations (CROs).
  • Proactively communicate project strategy, anticipate potential issues, and recommend appropriate resource decisions.
  • Communicate closely with internal and external team members across multiple disciplines to achieve project goals.

 

Professional Experience and Qualifications: 

  • Ph.D. degree in cell biology, molecular biology, infectious diseases or related discipline.
  • 10 years of hands-on drug discovery experience in an industrial setting in the antiviral and/or infectious therapeutic areas.
  • Proficiency with molecular biology and virology techniques: recombinant DNA techniques, RNA isolation, cell culture, transfections, virus production, amplification, viral quantitation, identification of optimal virus MOI etc. Possess a deep and broad understanding molecular biology and infectious diseases, including knowledge of preclinical and translational models.
  • Demonstrable hands-on experience in all aspects of hit-generation, advancing small molecule or antiviral drugs through lead optimization to candidate selection.
  • A clear understanding of drug discovery stage gates. Basic knowledge of or exposure to pharmacology, pharmacokinetics, medicinal chemistry, ADME, and toxicology.
  • Demonstrated leadership qualities with the ability to define strategy, develop project goals, and drive a program.
  • Experience working in dynamic, productive, cross-functional internal and external teams.
  • Track record of initiative and execution while maintaining the highest scientific rigor.
  • Possess outstanding organizational abilities with a collaborative, tactful, and goal-oriented working style.
  • Desire to work in a fast-paced start-up and a multitasking environment.

If you are ready to contribute to innovative research projects and be part of a growing company that is tackling some of the most pressing healthcare issues in modern medicine, please send us your CV and cover letter to info@pledge-tx.com

Job Type: Full-time, USA work permit, Equal Opportunity Employment

Canton (Greater Boston), MA

The Senior Research Associate will take part in all aspects of the Immune-Oncology drug discovery process. 

Job Description:

We seek an enthusiastic Scientist interested in taking part in all aspects of the Immune-Oncology drug discovery process. The opening is at our facility in Canton, MA and the Candidate will work directly with Immune-Oncology Program Leader.

The successful candidate will engage in assay development and small molecule screening. The ideal candidate will have great communication skills, excellent technical skills, exemplary attention to detail, thrive in a start-up environment and work well in a collaborative environment. This position will have the opportunity to become part of an exciting start-up company and make significant scientific contributions to numerous drug discovery projects.

Key Responsibilities:

  • Establish and execute a variety of biochemical/cell-based immunological in vitro assays
  • Investigate the effect of small molecules on the function of T and NK cells
  • Independently analyze, interpret, and present data at internal meetings
  • Maintain excellent electronic records of performed experiments and work with colleagues to develop companywide SOPs.
  • Collaborates cross-functionally with other team members to ensure that daily operations and timelines are met.
  • Participate in engagement with decision-makers and stakeholders

 

Professional Experience and Qualifications: 

  • BS with minimum 3 years or MS with 2 years of relevant experience in immuno-oncology or immunology in laboratory research settings. Industry experience is desired
  • Experiences with studying human T and NK cell functions
  • Hands-on experience with multi-color FACS, ELISA, western blot and cell-based assays to analyze immune cells in a BSL2 laboratory.
  • Small molecule experience desired
  • Proficiency in GraphPad and Flow Jo
  • Ability to work independently with minimal supervision
  • Strong analytical, organizational, communication and time management skills

 

If you are ready to contribute to innovative research projects and be part of a growing company that is tackling some of the most pressing healthcare issues in modern medicine, please send us your CV and cover letter to info@pledge-tx.com

Job Type: Full-time, USA work permit, Equal Opportunity Employment

Leuven, Belgium

The Laboratory Technician will engage in different areas of the company, including molecular biology, recombinant protein production, and assay development. 

Job Description:

We are looking for an enthusiastic and qualified Lab Technician interested in directly taking part in hit-to-lead drug discovery who will support our molecular biophysics program. This entry-level position is located at our state-of-the-art facility in Leuven.

The successful candidate will engage in different research areas of the company, including molecular biology, recombinant protein production, and assay development. You will work with a successful team of international senior scientists located in the EU and the USA. The ideal candidate will have great communication skills, keen attention to detail, excellent technical skills, and a passion for learning. This position will have the opportunity to become part of an exciting startup company and make significant scientific contributions to numerous drug discovery projects.

Key Responsibilities:

  • Technical support related to molecular biology, protein purification, and assay development
  • Contribute to laboratory operations, including the ordering of supplies and the maintenance of chemical and reagent inventories
  • Protocol and data management using an electronic Lab notebook
  • Provide support for routine scientific procedures including media and buffer preparation
  • Collect, clean, sterilized, and distributes glass and laboratory equipment and coordinates biohazard collections
  • Collaborate cross-functionally with other team members to ensure that daily operations and timelines are met.

 

Professional Experience and Qualifications: 

  • Bachelor’s in Biochemistry, Biotechnology, Biomedical Sciences, Biomedical Laboratory Technology, Chemistry or a similar degree allows you to fulfill the above-mentioned tasks.
  • Previous laboratory experience in the fields of biochemistry and/or molecular biology desired
  • Experience in bacterial culture and protein purification is a plus
  • Organized with a strong work ethic and the ability to juggle different tasks
  • Able to work in a team and willing to present data to our international partners
  • Fluent in English

 

If you are ready to contribute to innovative research projects and be part of a growing company that is tackling some of the most pressing healthcare issues in modern medicine, please send us your CV and cover letter to info@pledge-tx.com

Job Type: Full-time.